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KMID : 0043320040270111086
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1086 ~ p.1092
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Synthesis and Antinociceptive Activity of (5-Chloro-2(3H)-Benzoxazolon-3-yl) Propanamide Derivatives
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Onkol Tijen
Sahin M.Fethi
Yidirim Engin
Erol Kevser
Ito Shigero
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Abstract
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In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and spectral data and microanalysis. The compounds were tested for anti nociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of anti nociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound 5e, 5g, and 5h have been found to be significantly more active than the others and the standards in all the tests.
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KEYWORD
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5-Chloro-2(3H)-benzoxazolone, (5-Chloro-2(3H)-benzoxazolon-3-yl)propanamide, Antinociceptive activity
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